I am reading the book The Running Dream by Wendelin Van Draanen. I would say that the main setting would probably the school or outside, Because she has to go to school everyday and workout after school in the school and it would be outside because she always goes outside in the morning and runs and she works out she going running. She also loves doing both of those things school and running.
At the beginning of the book it is set is sad and in the morning or the middle of the day, she is in a hospital bed with half of her leg cut off. Then at the end of the book the setting is happy because she just ran a race with Rosa and finished and everyone is proud of her for accomplishing it.
One of the major events of the book was when she got in a car crash and the doctors had to cut off half of her leg. The weather was dark and sad and probably rain, it was a sad moment. Another major event was when her track team and school help her raise enough money for her to get a running leg. When that happens she is so happy and the sun us shining and everyone is happy they helped.
The setting changes the character in a lot of ways. In my book when it is sunny Jessica is happy and having fun with her friends or something, and when it is dark and rainy Jessica is sad or mad at something. People can have so many emotions.